Watch Vitesse vs Southampton Live Video Free Streaming Europa League
The only blot on the victory over Vitesse was the fact that new signing Jordy Clasie limped off during the second half.
The extent of the midfielder's hamstring injury has not been revealed, but it is believed that he will sit out this encounter.
As a result, England Under-21 international James Ward-Prowse could come into the side, while Koeman may also rotate his options with his side's place in the next round practically in the bag.
That may mean that the likes of Rodriguez, Juanmi and Cuco Martina will all earn places in the starting lineup.
Meanwhile, English youngsters Lewis Baker and Izzy Brown, both of whom are on loan from Chelsea, are expected to feature for the home team.
Vitesse possible starting lineup:
Room; Diks, Kashia, Leerdam, Achenteh; Baker, Nakamba, Vako, Brown; Djurdjevic, Oliinyk
Southampton possible starting lineup:
Stekelenburg; Cedric, Fonte, Yoshida, Martina, Wanyama, Ward-Prowse, Davis; Long, Rodriguez, Juanmi
Tag : Europa League