Real Madrid vs Celta Vigo Spanish La Liga Date: Saturday, 28 August 2016, Kick-Off: 01:15 GMT +7 Venue: Santiago Bernabeu (Madrid).
The 24-year-old midfielder has picked up a knock on his ankle and will not feature in the game at the Bernabeu, while manager Zinedine Zidane reiterated the importance of all members of his squad.
Karim Benzema and Cristiano Ronaldo - who won the UEFA's Best Player in Europe award for the 2015/16 season on Thursday - also remain unavailable, while rumours continue to swirl about the future of James Rodriguez and Raphael Varane.
"He's got some discomfort in his ankle. Last week he took a knock on his ankle and he's still not recovered. He left the training session and he won't be with us tomorrow," he told a pre-match press conference.
"Anything can happen until the 31st. Nobody is coming in, that's certain, but it's possible some may leave. This is the squad I've got and I'm happy with the players I have.
"There are injured players and some who still haven't come back yet. There's good depth, the season will be tough and we're going to need all of our players.
"I have 23 or 24 players and they're all going to get a game. Cristiano and Karim aren't playing and there are other players who have done well. When everyone is back, I'll make the decisions about who will play, that's not going to change.
"I want to be clear, every player is important and it's no surprise that they're all here. If they're playing for Real Madrid, it's because they're very good footballers."
Gareth Bale made a goalscoring return to the squad in their opening La Liga fixture of the season - netting twice as Los Blancos beat Real Sociedad 3-0 last weekend - and Zidane is looking forward to being back on home turf.
"It's exciting, it's the first home game and we want to play as well as we can," the former France international added.
"We started very well in La Liga at a difficult ground. Now we're up against a very good opponent, we know all about their quality and we're ready to play tomorrow. The fans will come to the ground and it's great for us to see a full stadium.
"We've got another tough opponent who play some good football, but our plan is the same as ever. It's our first game at home in front of our fans and we've got to come out the blocks well to try and get the three points."
Celta Vigo lost their opening La Liga fixture to new boys Leganes at the Balaidos Stadium, with Marcelo Diaz, Claudio Beauvue and goalkeeper Ruben Blanco Veiga injured for the trip to the Bernabeu.
Real Madrid vs Celta Vigo: Head-to-Head
Real Madrid are on a four match winning run against Celta Vigo. The latest meeting between the two sides was at Santiago Bernebeu in which Ronaldo run rout scoring four goals to hand Real a massive 7-1 win.
Real Madrid have also won in the the last five home matches against Celta, scoring 19 goals against 2 conceded.
Real Madrid vs Celta Vigo: Prediction
It is hard to see Celta trouble Real Madrid as they have suffered heavy losses when these two came face-to-face in recent seasons. They have conceded 11 goals in the two meetings of last season alone.
Moreover, Real Madrid hardly disappoint while they play at home. They have won in 12 of the last 13 games at the Bernebeu. They also averages 4.1 goals per games in the 10 home matches in La Liga since January 2016.
So, we are likely to see another expansive attacking game from the Los Blancos as they want nothing less than a win from the first competitive match of the season at the Santiago Bernebeu.
Real Madrid vs Celta Vigo: Betting Tips
Real Madrid to score over 2.5 goals at 1.66.
Gareth Bale to Score any-time at 1.70.